Nancy Isime was born in Edo State, she is a nollywood actress, TV presenter/host.
She lost her Mum at age 5 and was brought up solely by her Dad. She grew up in Lagos, where she had her primary and junior secondary education.  Afterwards, she left for Benin, where she had her senior secondary education. Nancy did a six-month basic course at the University of Port Harcourt and a Diploma in Social Work at the University of Lagos.

In 2009, Nancy Isime won the Miss Valentine International beauty pageant, and finished second in the Miss Telecoms Nigeria beauty contest. As a model she has worked for the likes of “House of Marie”, “Ade Bakere”, “Adebayo Jones”, “Zizi Cardow”, “Shakara Couture”, “Konga Online” and others.
Nancy Isime once said: “It is all about the ability to always try and to keep coming back until you get your big break.

Isime is also a television presenter, in 2016 she replaced Toke Makinwa as the presenter of the popular show Trending on HipTV. She also co-hosted the 2019 and 2020 edition of The Headies award with Reminisce and Bovi respectively.
Nancy Isime currently anchors her own show called , “The Nancy Isime Show”.