Leaders Atletico Madrid suffered a rare La Liga defeat as Marcos Acuna’s header earned Sevilla victory.
Argentina defender Acuna was unmarked when he nodded a cross by former Manchester City player Jesus Navas past Jan Oblak.
Oblak had earlier saved Lucas Ocampos’ penalty after Saul Niguez brought down Ivan Rakitic.
Atletico, chasing a first league title since 2014, are three points clear at the top with nine games left.
Third-placed Barcelona will move one point behind Atletico if they beat 16th-placed Real Valladolid on Monday (20:00 BST).
![Atletico Madrid are three points clear at the top of La Liga with nine games to play](https://i0.wp.com/ichef.bbci.co.uk/onesport/cps/624/cpsprodpb/128F8/production/_117842067_00top.png?w=665&ssl=1)
On a frustrating night for Atletico, Mario Hermoso wasted a chance to equalise against fourth-placed Sevilla when he blazed over from 15 yards.
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Atletico pressed forward to try to avoid their third league defeat of the season, but substitute Angel Correa was denied by Yassine Bounou’s save in stoppage time.